Deep rests Science in the Mind
as Magic deep in the Heart;
Those on which the Will is strong,
Those will reign on Their behalf.
In my opinion, part of the "charm" of Glest is that it has a solid foundation in terms of aesthetics and background, yet it is still open for everyone to imagine the details (as silent did to an incredible extent in his/her version).
Once upon a time (hehe) I asked Tucho to make a map of "The world of Glest", since it´s not stated anywhere that Glest takes place in Europe. Unfortunately he was really busy making models, textures and animations, so the map was never done. Sometimes I still wonder how that map would look like...
Anyways, talking on the Will, I´d say it´s not something like the Force, but more the courage to persist against adversity. -Yikes, I have just cut a thousand possible stories...
Ok, let´s say that what I wrote above is not "canon". However, there will never be midichlorians in Glest, period. XD