When we were testing yesterday, MegaGlest constantly caused about 350 % CPU load (100% = 1 of my 4 cores fully loaded), 180% of which were on a single core, meaning this very thread was way too busy, overloading one of my cores constantly. This makes the game react very slowly, and unpleasent to play, similar but different as network inflicted lag. It also consumes a lot of power. Those values are taken from "htop" output.
My understanding is that PT (titi|son), the other client on this game, made similar experiences, and has a more modern dedicated video card than my atibox has.